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Title
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Vitamin E deficiency
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ImagePath
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System
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vitamin deficiency
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Overview
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Deficiency of tocopherol leading to oxidative damage to RBCs and neurons.
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Pathophysiology
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Fat‑malabsorption (CF, cholestasis), abetalipoproteinemia. ↓ antioxidant protection, RBC hemolysis, axonal degeneration.
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Presentation
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Hemolytic anemia, acanthocytosis, spinocerebellar ataxia, loss of dorsal column and spinocerebellar tract sensation, muscle weakness.
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Diagnosis
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↓ Serum α‑tocopherol; ↑ plasma hemolysis with H₂O₂ test.
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Management
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Fat‑soluble vitamin formulation 100‑400 IU/day; address malabsorption etiology.
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Epidemiology
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Rare; preterm infants at risk.
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Tags
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