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Card
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Title
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Rickets
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ImagePath
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System
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bone mineralization disorder
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Overview
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Vitamin D deficiency in growing bone leading to defective mineralization of osteoid.
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Pathophysiology
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Low calcitriol leads to ↓ Ca‑Pi product impairing endochondral ossification at growth plates.
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Presentation
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Bowing of legs, frontal bossing, craniotabes, widening of wrist, rachitic rosary, delayed fontanelle closure.
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Diagnosis
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Same labs as vit D deficiency; wrist X‑ray shows cupping and fraying metaphyses.
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Management
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Vitamin D 1000‑2000 IU/day, calcium; treat underlying malabsorption or renal disease.
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Epidemiology
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Exclusively breast‑fed infants without supplementation at highest risk.
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Tags
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